Yiming Tang (唐一鸣)
Computational physicist working on the intersection of physics and biology.

Research Output

Last updated: May 25, 2026
57
Publications
17
First/Corresponding
1,638
Total Citations
23
H-index

2026

57.

Yanning Zhen#, Yuan Tan#, Yiming Tang, Tomas Sneideris, Hannes Ausserwoger, Jitao Wen, Tuomas P. J. Knowles, Sarah Perrett*, Guanghong Wei*, Si Wu*

NPM1 Undergoes Salt-Dependent Reentrant Phase Separation Driven by IDR Conformational Plasticity and Electrostatic Crosstalk Journal Article

In: Small, vol. 22, no. 28, pp. e14678, 2026.

Links

56.

Xun Sun#, Yiming Tang#, Xue Wang#, Guadalupe Pereira Curia, Rebecca Sternke-Hoffmann, Cecilia Morman, Juan Atilio Gerez, Roland Riek, Guanghong Wei*, Jinghui Luo*

Alzheimer’s Aβ catalyzes Tau phase separation and aggregation via early nanocluster solubilization Journal Article

In: Nature Communications, vol. 17, pp. 3755, 2026.

Links

55.

Yan Zhang#, Tong Pan#, Sarah Guerin, Jiahao Zhang*, Yiming Tang, Zengfeng Qiu, Qi Li, Jiaojiao Zhang, Feng Wei, Jiqian Wang, Rusen Yang, Deqing Mei, Damien Thompson, Guanghong Wei*, Hai Xu*, Kai Tao*

Underlying polymorphism: superhelical crystallization induces architectural and functional diversity Journal Article

In: Small, vol. 22, no. 6, pp. e10542, 2026.

Links

2025

54.

Jitao Wen#, Yiming Tang#, Tomas Sneideris, Hannes Ausserwöger, Liu Hong, Tuomas PJ Knowles, Sarah Perrett*, Guanghong Wei*, Si Wu*

Direct observation of the conformational transitions in tau and their correlation with phase behavior Journal Article

In: JACS Au, vol. 5, no. 9, pp. 4268–4280, 2025.

Links

53.

Xinyuan Fan#, Yiming Tang#, Jiahao Zhang, Kang Ma, Zhengyu Xu, Yuying Liu, Bin Xue, Yi Cao, Deqing Mei, Wei Wang, Guanghong Wei*, Kai Tao*

Gaseous Synergistic Self-Assembly and Arraying to Develop Bio-Organic Photocapacitors for Neural Photostimulation Journal Article

In: Advanced Science, vol. 12, no. 15, pp. 2410471, 2025.

Links

52.

Tong Pan, Yuan Tan, Xuewei Dong, Yiming Tang, Zhongyuan Yang, Yujie Chen*, Guanghong Wei*

Elucidating How Terminal Capping of Tau Hexapeptide PHF6 Modulates the Interactions between PHF6 Fibrils and Membranes Journal Article

In: The Journal of Physical Chemistry B, vol. 129, no. 22, pp. 5449–5463, 2025.

Links

51.

Yuan Tan, Yujie Chen, Tong Pan, Yiming Tang, Xianshi Liu, Yawei Yu, Guanghong Wei*

Computational Exploration of the Inhibitory Mechanism of mRNA against the Phase Separation of hnRNPA2 Low Complexity Domains Journal Article

In: Journal of Chemical Information and Modeling, vol. 65, no. 9, pp. 4643–4654, 2025.

Links

50.

Yoav Dan#, Zohar A Arnon#, Yiming Tang#, Mathar Kravikass, Yun Zhou, Rajkumar Misra, Om Shanker Tiwari, Linda JW Shimon, Roy Beck, Ehud Gazit, Guanghong Wei, Lihi Adler-Abramovich*

Effect of solvent-induced packing transitions on N-capped diphenylalanine peptide crystal growth Journal Article

In: Nature Communications, vol. 16, no. 1, pp. 6106, 2025.

Links

49.

Haoxin Sun, Jingbo Wei, Yiming Tang, Tianjing Guo, Guanghong Wei, Jiangtao Lei*

Comparative study of a variant neural relational inference deep learning model and dynamical network analysis for p53-DNA allosteric interactions Journal Article

In: Journal of Molecular Biology, pp. 169374, 2025.

Links

48.

Hui Yuan#, Yiming Tang#, Elma Naranjo#, Pierre‐Andre Cazade, Yifei Yao, Vijayakanth Thangavel, Rusen Yang, Sigal Rencus‐Lazar, Damien Thompson, Linda JW Shimon, Guanghong Wei*, Xi Chen*, Ehud Gazit*

Discrete Actuation of Water-Responsive Crystalline Metal–Peptide Frameworks Journal Article

In: Angewandte Chemie, vol. 137, no. 43, pp. e202513629, 2025.

Links

47.

Yiming Tang#, Jitao Wen#, Zhongyuan Yang#, Yifei Yao, Shaoshuai He, Jiyuan Zeng, Xuewei Dong, Qin Qiao, Yun Zhou, Sarah Perrett, Si Wu*, Guanghong Wei*

Dissecting the Molecular Determinants of α-synuclein Phase Separation and Condensate Aging: The Pivotal Role of β-Sheet-Rich Motifs Journal Article

In: Advanced Science, vol. 12, no. 44, pp. e11545, 2025.

Links

46.

Yiming Tang#, Zhongyuan Yang#, Junli Yang, Jiyuan Zeng, Yuan Tan, Yifei Yao, Wei Ji*, Ehud Gazit*, Guanghong Wei*

Stoichiometry-Controlled Structural Transformation of Diphenylalanine Nanoassemblies through Coassembly with Charged Dipeptides Journal Article

In: JACS Au, vol. 5, no. 10, pp. 5098–5110, 2025.

Links

45.

Vivek Vishwanath Adole, Zichao Wang, Yiming Tang, Gayatri Mishra, Ipsita Sahu, Guanghong Wei*, Priyadarshi Chakraborty*

Histidine Containing Minimalistic-Peptide-Based Nanostructured Hydrogel for Multiple Enzyme-Mimicking Catalytic Activities Journal Article

In: Small, vol. 21, no. 51, pp. e11661, 2025.

Links

2024

44.

Jiyuan Zeng#, Zhongyuan Yang#, Yiming Tang*, Guanghong Wei*

Emerging Frontiers in conformational exploration of disordered proteins: integrating autoencoder and molecular simulations Journal Article

In: ACS Chemical Neuroscience, vol. 15, no. 23, pp. 4241–4244, 2024.

Links

43.

Yiming Tang*, Zhongyuan Yang, Yifei Yao, Yun Zhou, Yuan Tan, Zichao Wang, Tong Pan, Rui Xiong, Junli Sun, Guanghong Wei*

Recent advances in protein conformation sampling by combining machine learning with molecular simulation Journal Article

In: Chinese Physics B, vol. 33, no. 3, pp. 030701, 2024.

Links

42.

Jiyuan Zeng, Yiming Tang, Xuewei Dong, Fangying Li, Guanghong Wei*

Influence of ALS-linked M337V mutation on the conformational ensembles of TDP-43321–340 peptide monomer and dimer Journal Article

In: Proteins: Structure, Function, and Bioinformatics, vol. 92, no. 9, pp. 1059–1069, 2024.

Links

41.

Ipsita Sahu, Yiming Tang, Zichao Wang, Souvik Naskar, Thangavel Vijayakanth, Vivek Vishwanath Adole, Guanghong Wei*, Priyadarshi Chakraborty*

Bioinspired functional self-healing hydrogels from a minimalistic dipeptide building block Journal Article

In: Journal of Materials Chemistry A, vol. 12, no. 7, pp. 4169–4183, 2024.

Links

40.

Zenghui Lao#, Yiming Tang#, Xuewei Dong, Yuan Tan, Xuhua Li, Xianshi Liu, Le Li, Cong Guo*, Guanghong Wei*

Elucidating the reversible and irreversible self-assembly mechanisms of low-complexity aromatic-rich kinked peptides and steric zipper peptides Journal Article

In: Nanoscale, vol. 16, no. 8, pp. 4025–4038, 2024.

Links

39.

Yujie Chen#, Xun Sun#, Yiming Tang, Yuan Tan, Cong Guo, Tong Pan, Xuefeng Zhang, Jinghui Luo*, Guanghong Wei*

Pathogenic Mutation ΔK280 Promotes Hydrophobic Interactions Involving Microtubule-Binding Domain and Enhances Liquid-Liquid Phase Separation of Tau Journal Article

In: Small, pp. 2406429, 2024.

Links

38.

Yawei Yu, Qian Liu, Jiyuan Zeng, Yuan Tan, Yiming Tang, Guanghong Wei*

Multiscale simulations reveal the driving forces of p53C phase separation accelerated by oncogenic mutations Journal Article

In: Chemical Science, vol. 15, no. 32, pp. 12806–12818, 2024.

Links

2023

37.

Yiming Tang, Yifei Yao, Zhongyuan Yang, Yun Zhou, Zichao Wang, Guanghong Wei

Pathological aggregation and liquid-liquid phase separation of proteins associated with neurodegenerative diseases Journal Article

In: Synthetic Biology Journal, vol. 4, no. 3, pp. 590, 2023.

Links

36.

Fangying Li, Yujie Chen, Yiming Tang, Xianshi Liu, Guanghong Wei*

Dissecting the effect of ALS mutation G335D on the early aggregation of the TDP-43 amyloidogenic core peptide: Helix-to-β-Sheet transition and conformational shift Journal Article

In: Journal of Chemical Information and Modeling, vol. 63, no. 11, pp. 3579–3590, 2023.

Links

35.

Yun Zhou#, Yifei Yao#, Zhongyuan Yang, Yiming Tang, Guanghong Wei*

Naphthoquinone–dopamine hybrids disrupt α-synuclein fibrils by their intramolecular synergistic interactions with fibrils and display a better effect on fibril disruption Journal Article

In: Physical Chemistry Chemical Physics, vol. 25, no. 20, pp. 14471–14483, 2023.

Links

34.

Yuan Tan, Yujie Chen*, Xianshi Liu, Yiming Tang, Zenghui Lao, Guanghong Wei*

Dissecting how ALS-associated D290V mutation enhances pathogenic aggregation of hnRNPA2286–291 peptides: Dynamics and conformational ensembles Journal Article

In: International Journal of Biological Macromolecules, vol. 241, pp. 124659, 2023.

Links

33.

Zhongyuan Yang, Yifei Yao, Yun Zhou, Xuhua Li, Yiming Tang*, Guanghong Wei*

EGCG attenuates α-synuclein protofibril-membrane interactions and disrupts the protofibril Journal Article

In: International Journal of Biological Macromolecules, vol. 230, pp. 123194, 2023.

Links

2022

32.

Le Li, Xuewei Dong, Yiming Tang, Zenghui Lao, Xuhua Li, Jiangtao Lei, Guanghong Wei*

Deciphering the mechanisms of HPV E6 mutations in the destabilization of E6/E6AP/p53 complex Journal Article

In: Biophysical Journal, vol. 121, no. 9, pp. 1704–1714, 2022.

Links

31.

Zenghui Lao, Xuewei Dong, Xianshi Liu, Fangying Li, Yujie Chen, Yiming Tang, Guanghong Wei*

Insights into the atomistic mechanisms of phosphorylation in disrupting liquid–liquid phase separation and aggregation of the FUS low-complexity domain Journal Article

In: Journal of chemical information and modeling, vol. 62, no. 13, pp. 3227–3238, 2022.

Links

30.

Yawei Yu, Xuewei Dong, Yiming Tang, Le Li, Guanghong Wei*

Mechanistic insight into the destabilization of p53TD tetramer by cancer-related R337H mutation: a molecular dynamics study Journal Article

In: Physical Chemistry Chemical Physics, vol. 24, no. 8, pp. 5199–5210, 2022.

Links

29.

Rajkumar Misra, Yiming Tang, Yujie Chen, Priyadarshi Chakraborty, Francesca Netti, Thangavel Vijayakanth, Linda JW Shimon, Guanghong Wei*, Lihi Adler‐Abramovich*

Exploiting minimalistic backbone engineered γ-phenylalanine for the formation of supramolecular co-polymer Journal Article

In: Macromolecular rapid communications, vol. 43, no. 19, pp. 2200223, 2022.

Links

28.

Yifei Yao#, Yiming Tang#, Yun Zhou, Zhongyuan Yang, Guanghong Wei*

Baicalein exhibits differential effects and mechanisms towards disruption of α-synuclein fibrils with different polymorphs Journal Article

In: International Journal of Biological Macromolecules, vol. 220, pp. 316–325, 2022.

Links

27.

Fangying Li, Yujie Chen*, Xianshi Liu, Yiming Tang, Xuewei Dong, Guanghong Wei*

Atomistic insights into A315E mutation-enhanced pathogenicity of TDP-43 core fibrils Journal Article

In: ACS Chemical Neuroscience, vol. 13, no. 18, pp. 2743–2754, 2022.

Links

2021

26.

Wei Ji*, Yiming Tang, Pandeeswar Makam, Yifei Yao, Ranran Jiao, Kaiyong Cai, Guanghong Wei*, Ehud Gazit*

Expanding the structural diversity and functional scope of diphenylalanine-based peptide architectures by hierarchical coassembly Journal Article

In: Journal of the American Chemical Society, vol. 143, no. 42, pp. 17633–17645, 2021.

Links

25.

Xuewei Dong, Santu Bera, Qin Qiao, Yiming Tang, Zenghui Lao, Yin Luo, Ehud Gazit*, Guanghong Wei*

Liquid–liquid phase separation of tau protein is encoded at the monomeric level Journal Article

In: The journal of physical chemistry letters, vol. 12, no. 10, pp. 2576–2586, 2021.

Links

24.

Santu Bera, Xuewei Dong, Bankala Krishnarjuna, Shannon A Raab, David A Hales, Wei Ji, Yiming Tang, Linda JW Shimon, Ayyalusamy Ramamoorthy, David E Clemmer, Guanghong Wei, Ehud Gazit*

Solid-state packing dictates the unexpected solubility of aromatic peptides Journal Article

In: Cell Reports Physical Science, vol. 2, no. 4, 2021.

Links

23.

Yiming Tang#, Santu Bera#, Yifei Yao, Jiyuan Zeng, Zenghui Lao, Xuewei Dong, Ehud Gazit*, Guanghong Wei*

Prediction and characterization of liquid-liquid phase separation of minimalistic peptides Journal Article

In: Cell Reports Physical Science, vol. 2, no. 9, 2021.

Links

22.

Xuewei Dong, Yiming Tang, Chendi Zhan, Guanghong Wei*

Green tea extract EGCG plays a dual role in Aβ42 protofibril disruption and membrane protection: A molecular dynamic study Journal Article

In: Chemistry and physics of lipids, vol. 234, pp. 105024, 2021.

Links

21.

Yiming Tang, Yifei Yao, Guanghong Wei*

Unraveling the allosteric mechanism of four cancer-related mutations in the disruption of p53-DNA interaction Journal Article

In: The Journal of Physical Chemistry B, vol. 125, no. 36, pp. 10138–10148, 2021.

Links

20.

Chendi Zhan, Zenghui Lao, Yiming Tang, Qin Qiao, Guanghong Wei*

Natural stereoisomeric flavonoids exhibit different disruptive effects and the mechanism of action on Aβ 42 protofibril Journal Article

In: Chemical Communications, vol. 57, no. 35, pp. 4267–4270, 2021.

Links

19.

Priyadarshi Chakraborty, Hadas Oved, Darya Bychenko, Yifei Yao, Yiming Tang, Shai Zilberzwige‐Tal, Guanghong Wei, Tal Dvir, Ehud Gazit*

Nanoengineered peptide-based antimicrobial conductive supramolecular biomaterial for cardiac tissue engineering Journal Article

In: Advanced Materials, vol. 33, no. 26, pp. 2008715, 2021.

Links

2020

18.

Priyadarshi Chakraborty, Yiming Tang, Tomoya Yamamoto, Yifei Yao, Tom Guterman, Shai Zilberzwige‐Tal, Nofar Adadi, Wei Ji, Tal Dvir, Ayyalusamy Ramamoorthy, Guanghong Wei*, Ehud Gazit*

Unusual two-step assembly of a minimalistic dipeptide-based functional hypergelator Journal Article

In: Advanced Materials, vol. 32, no. 9, pp. 1906043, 2020.

Links

17.

Chendi Zhan, Yujie Chen, Yiming Tang, Guanghong Wei*

Green tea extracts EGCG and EGC display distinct mechanisms in disrupting Aβ42 protofibril Journal Article

In: ACS chemical neuroscience, vol. 11, no. 12, pp. 1841–1851, 2020.

Links

16.

Kai Tao#*, Yiming Tang#, Sigal Rencus‐Lazar, Yifei Yao, Bin Xue, Sharon Gilead, Guanghong Wei*, Ehud Gazit*

Bioinspired Supramolecular Packing Enables High Thermo-Sustainability Journal Article

In: Angewandte Chemie, vol. 132, no. 43, pp. 19199–19203, 2020.

Links

15.

Yu Zou, Zhenyu Qian, Yehong Gong, Yiming Tang, Guanghong Wei*, Qingwen Zhang*

Critical nucleus of Greek-key-like core of α-synuclein protofibril and its disruption by dopamine and norepinephrine Journal Article

In: Physical Chemistry Chemical Physics, vol. 22, no. 1, pp. 203–211, 2020.

Links

14.

Yiming Tang, Yifei Yao, Guanghong Wei*

Expanding the structural diversity of peptide assemblies by coassembling dipeptides with diphenylalanine Journal Article

In: Nanoscale, vol. 12, no. 5, pp. 3038–3049, 2020.

Links

13.

Cuiqin Bai, Zenghui Lao, Yujie Chen, Yiming Tang, Guanghong Wei*

Pristine and hydroxylated fullerenes prevent the aggregation of human islet amyloid polypeptide and display different inhibitory mechanisms Journal Article

In: Frontiers in Chemistry, vol. 8, pp. 51, 2020.

Links

12.

Yifei Yao, Yiming Tang, Guanghong Wei*

Epigallocatechin gallate destabilizes α-synuclein fibril by disrupting the E46–K80 salt-bridge and inter-protofibril interface Journal Article

In: ACS Chemical Neuroscience, vol. 11, no. 24, pp. 4351–4361, 2020.

Links

11.

Le Li, Xuhua Li, Yiming Tang, Zenghui Lao, Jiangtao Lei, Guanghong Wei*

Common cancer mutations R175H and R273H drive the p53 DNA-binding domain towards aggregation-prone conformations Journal Article

In: Physical Chemistry Chemical Physics, vol. 22, no. 17, pp. 9225–9232, 2020.

Links

10.

Yiming Tang, Yifei Yao, Guanghong Wei*

Structural and dynamical mechanisms of a naturally occurring variant of the human prion protein in preventing prion conversion Journal Article

In: Chinese Physics B, vol. 29, no. 10, pp. 108710, 2020.

Links

9.

Priyadarshi Chakraborty, Yiming Tang, Tom Guterman, Zohar A Arnon, Yifei Yao, Guanghong Wei*, Ehud Gazit*

Co-assembly between Fmoc diphenylalanine and diphenylalanine within a 3D fibrous viscous network confers atypical curvature and branching Journal Article

In: Angewandte Chemie, vol. 132, no. 52, pp. 23939–23947, 2020.

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2019

8.

Santu Bera, Sudipta Mondal, Yiming Tang, Guy Jacoby, Elad Arad, Tom Guterman, Raz Jelinek, Roy Beck, Guanghong Wei, Ehud Gazit*

Deciphering the rules for amino acid co-assembly based on interlayer distances Journal Article

In: ACS nano, vol. 13, no. 2, pp. 1703–1712, 2019.

Links

7.

Vasantha Basavalingappa#, Tom Guterman#, Yiming Tang, Sivan Nir, Jiangtao Lei, Priyadarshi Chakraborty, Lee Schnaider, Meital Reches, Guanghong Wei*, Ehud Gazit*

Expanding the functional scope of the fmoc-diphenylalanine hydrogelator by introducing a rigidifying and chemically active urea backbone modification Journal Article

In: Advanced Science, vol. 6, no. 12, pp. 1900218, 2019.

Links

6.

Zenghui Lao, Yujie Chen, Yiming Tang, Guanghong Wei*

Molecular dynamics simulations reveal the inhibitory mechanism of dopamine against human islet amyloid polypeptide (hIAPP) aggregation and its destabilization effect on hIAPP protofibrils Journal Article

In: ACS Chemical Neuroscience, vol. 10, no. 9, pp. 4151–4159, 2019.

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5.

Vasantha Basavalingappa, Santu Bera, Bin Xue, Ido Azuri, Yiming Tang, Kai Tao, Linda JW Shimon, Michael R Sawaya, Sofiya Kolusheva, David S Eisenberg, Leeor Kronik, Yi Cao, Guanghong Wei, Ehud Gazit*

Mechanically rigid supramolecular assemblies formed from an Fmoc-guanine conjugated peptide nucleic acid Journal Article

In: Nature communications, vol. 10, no. 1, pp. 5256, 2019.

Links

4.

Hongqing Wang, Qian Xu, Zhihua Liu, Yiming Tang, Guanghong Wei, Y Ron Shen, Wei-Tao Liu*

Gate-controlled sum-frequency vibrational spectroscopy for probing charged oxide/water interfaces Journal Article

In: The Journal of Physical Chemistry Letters, vol. 10, no. 19, pp. 5943–5948, 2019.

Links

2018

3.

Yiming Tang, Guanghong Wei

Dissecting the structural mechanism of a naturally occuring variant of the prion protein in preventing prion disease Journal Article

In: Biophysical Journal, vol. 114, no. 3, pp. 234a, 2018.

Links

2.

Hongsheng Qian, Yu Zou, Yiming Tang, Yehong Gong, Zhenyu Qian, Guanghong Wei*, Qingwen Zhang*

Proline hydroxylation at different sites in hypoxia-inducible factor 1α modulates its interactions with the von Hippel–Lindau tumor suppressor protein Journal Article

In: Physical Chemistry Chemical Physics, vol. 20, no. 27, pp. 18756–18765, 2018.

Links

1.

Yuxiang Mo, Sayanti Brahmachari, Jiangtao Lei, Sharon Gilead, Yiming Tang, Ehud Gazit*, Guanghong Wei*

The inhibitory effect of hydroxylated carbon nanotubes on the aggregation of human islet amyloid polypeptide revealed by a combined computational and experimental study Journal Article

In: ACS chemical neuroscience, vol. 9, no. 11, pp. 2741–2752, 2018.

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